Abstract
Hypoglycemic and hypolipidemic effects of P. linteus have been observed in numerous studies, but the underlying molecular mechanisms are unclear. In this study, we prepared P. linteus extract (PLE) from mycelia of solid-state culture, and evaluated its hypoglycemic and hypolipidemic effects in rat models of high-fat diet (HFD)-induced and low-dose streptozotocin (STZ)-induced type 2 diabetes. PLE treatment effectively reduced blood glucose levels, and improved insulin resistance and lipid and lipoprotein profiles. The hypoglycemic effect of PLE was based on inhibition of key hepatic gluconeogenesis enzymes (FBPase, G6Pase) expression and hepatic glycogen degradation, and consequent reduction of hepatic glucose production. PLE also: (i) enhanced expression of CPT1A and ACOX1 (key proteins involved in fatty acid β-oxidation) and low-density lipoprotein receptor (LDLR) in liver, thus promoting clearance of triglycerides and LDL-C; (ii) inhibited expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in liver, thus reducing cholesterol production; (iii) displayed strong hepatoprotective and renal protective effects. Our findings indicate that PLE has strong potential functional food application in adjuvant treatment of type 2 diabetes with dyslipidemia.
Highlights
Diabetes is a metabolic disease characterized by high blood glucose level resulting from insulin secretion deficiency, insulin resistance, or these two factors in combination [1].It causes progressive harmful effects to kidneys, heart and other organs, with associated diseases, and reduces quality of life for patients [1,2]
Our findings indicate that P. linteus extract (PLE) has strong potential functional food application in adjuvant treatment of type 2 diabetes with dyslipidemia
Hypoglycemic and hypolipidemic effects, and underlying molecular mechanisms, of mycelial P. linteus extract (PLE) from solid-state culture were evaluated in type 2 diabetic rat models based on high-fat diet or low-dose streptozotocin treatment
Summary
Diabetes is a metabolic disease characterized by high blood glucose level (hyperglycemia) resulting from insulin secretion deficiency, insulin resistance, or these two factors in combination [1]. P. linteus [18] has a >2000-year history of applications in traditional Chinese medicine, and is widely used in many eastern Asian countries as a functional food [19] It is rich in polysaccharides and other small molecules, and has well documented anti-cancer [20], anti-oxidative [21,22], anti-inflammatory [23,24,25], hepatoprotective [26], and antibacterial [27] effects. Hypoglycemic and hypolipidemic effects, and underlying molecular mechanisms, of mycelial P. linteus extract (PLE) from solid-state culture were evaluated in type 2 diabetic rat models based on high-fat diet or low-dose streptozotocin treatment
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