Abstract
ABSTRACT The possible hypoglycemic and hypolipidemic potentials of an aqueous extract of Abrus precatorius seeds was investigated in diabetic Wistar rats induced with streptozotocin (STZ). An extract treatment dose of 100 mg/kg and 200 mg/kg body weight to the diabetes-induced rats resulted in significant reduction (p < 0.05) in blood glucose levels. Use of the extract also prevented the decrease in body weight observed in the diabetic rats as compared with non-diabetic controls. A significant increase (p < 0.05) in serum total cholesterol, LDL-cholesterol and triacylglycerol levels observed in the STZ-induced diabetic rats approached normal levels in animals treated with A. precatorius extract. The strong antihypoglycemic and antihypolipidemic potential A. precatorius seeds reduced the atherogenic risk predictor indices HDL-C/TC and LDL-C/HDL-C in the STZ-induced diabetic rats to near normal. The action of A. precatorius was dose-dependant.
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