Hypoglycemic and Antioxidant Activity of Ficus arnottiana Leaves: Insights into Diabetes Management and Oxidative Stress Mitigation.

Abstract

Objective:To investigate the hypoglycaemic properties of a methanolic extract from Ficus arnottiana leaves in rodent models. Results: The findings revealed that F. arnottiana leaves key active components (psoralen), notably coumarins, attributing to its prowess in combating hyperglycemia. In addition, the study observed that methanolic extract displayed the highest activity, specifically at a dosage of 500 mg/kg. This was in comparison to the standard reference, glimepiride, which exhibited activity at a dosage of 5 mg/kg. This finding suggests a potentially enhanced or superior effect associated with the methanolic extract in the context of the study, Furthermore,the finding of the result showed that the application of methanolic extract at a concentration of 500 mg/kg resulted in a noteworthy mitigation of oxidative stress and increased blood glucose levels. This was demonstrated by a significant decrease in oxidative stress markers, fasting blood glucose levels, OGT, and tissue damage in the experimental model, the control group was compared. Conclusion: Methanolic extract of F. arnottiana exhibits efficacious hypoglycemic activity alongside ensured safety”.