Abstract
To consider potentially new hypoglycemic and antihyperlipidemic sources, aqueous extracts from four Korean medicinal plants, Chrysanthemum coronarium, Dioscorea batatas, Morus alba, Citrus unshiu, were investigated in alloxan-induced diabetic rats. To induce diabetes, 36 rats were administered alloxan orally (120 mg/kg body weight) for 2 weeks and among those 6 rats were used as a diabetic control. Effect of extracts from four medicinal plants on blood glucose levels of diabetic rats was determined at various time interval for 9 h after oral administration of the first extract at 100 mg dose /kg body weight. In addition, GOT, GPT, LDH, total cholesterol (TC) and triglyceride (TG) were determined 7 days after daily oral administration of each extract. The glucose levels of diabetic rats treated with C. coronarium and M. alba were significantly decreased, respectively, at 3 h and 5 h after administration (p<0.05). The enzyme activities of GOT, GPT and LDH of diabetic rats were also decreased in diabetic rats treated with four plant extracts respectively. In particular, the administration of extract from M. alba tends to bring the GOT, GPT and LDH values of diabetic rats to near normal. There was no significant difference in TC between diabetic control and diabetic rats treated, respectively, with extracts of C. coronarium, D. batatas and M. alba, except C.unshiu extract showing a significant decrease when compared to the diabetic control. The TC value was brought down by 33.3% fall from the value of diabetic rats, which shows more decrease than that of glibenclamide-treated ones. There was a significant difference in TG between the diabetic control and diabetic rats treated, respectively, with extracts of C. coronarium, D. batatas, M. alba and C.unshiu. The results suggest that the administration of C. coronarium and M. alba have a hypoglycemic effect in diabetic rats and their effect was equivalent to that of glibenclamide. The administration of C.unshiu shows more antihyperlipidemic effect than antidiabetic effect.
Highlights
Diabetes mellitus is a complex disorder that characterized by hyperglycemia resulting from malfunction in insulin secretion and/or insulin action both causing by impaired metabolism of glucose, lipids and protein[1]
In the present study the aqueous extracts of four Korean diet plants, C. coronarium, D. batatas, M. alba and C. unshiu were evaluated for the potential antidiabetic and antihyperlipidemic effect on alloxan-induced diabetic rats and to compare the effect with glibenclamide
Effect of experimental plants on plasma glucose levels: The effect of aqueous extracts from four medicinal plants on the blood glucose levels of experimental animals was determined at various time interval for 9 h after oral administration at 100 mg dose kg-1 b.wt. (Fig. 1 and Table 2)
Summary
Diabetes mellitus is a complex disorder that characterized by hyperglycemia resulting from malfunction in insulin secretion and/or insulin action both causing by impaired metabolism of glucose, lipids and protein[1]. Some medicinal plants have been reported to be useful in diabetes worldwide and have been used empirically as antidiabetic and antihyperlipidemic remedies[5,6,7,8,9,10] Antihyperglycemic effects of these plants are attributed to their ability to restore the function of pancreatic tissues by causing an increase in insulin output or inhibit the intestinal absorption of glucose or to the facilitation of metabolites in insulin dependent processes. In the present study the aqueous extracts of four Korean diet plants, C. coronarium, D. batatas, M. alba and C. unshiu were evaluated for the potential antidiabetic and antihyperlipidemic effect on alloxan-induced diabetic rats and to compare the effect with glibenclamide. We determined the effect of aqueous extracts from four plants on glucose, GOT, GPT, LDH, total cholesterol (TC) and triglyceride (TG) in the blood
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