HYPOGLYCEMIC ACTIVITY OF TEN MEDICINAL PLANTS EXTRACT IN GLUCOSE INDUCED MICE

Abstract

Objective: To evaluate and compare the hypoglycemic activity of ten medicinal plantsextract that are used empirically to treat hyperglycemia in Indonesia, in order to determineplant with the most potential as a hypoglycemic agent.Methods: Activity test was conducted in Swiss Webster glucose induced mice with glucosetolerance test. The ethanolic extracts of Mangiferaindica L. leaves, Perseaamericana Mill.leaves, Acoruscalamus L. rhizome, Phyllanthusniruri L. herb, Syzigiumcumini (L.) skeelsbark, Zingiberofficinale Roscoe rhizome, Moringaoleifera Lam. leaves, TamarindusindicaL. seed, Momordicacharantia L. fruits and Azadirachtaindica A. juss leaves, which weregiven orally at the same dose of 300 mg/kg bw. The blood samples wereused for determination of glucose level examination using glucose meter and test strips (AccuChek).Results: The ethanolic extract of Mangiferaindica L. leaves has the best activity in reductionof blood glucose level in mice, followed by Zingiberofficinale Roscoe rhizome,Acoruscalamus L. rhizome, Tamarindusindica L. seed.,MomordicacharantiaL. fruit., Syzigiumcumini (L.) skeels bark, Phyllanthusniruri L. herb., Perseaamericana Mill. leaves, andAzadirachtaindica A. juss leaves.Conclusion: Results of the present study suggest the potential use of Mangiferaindica L.leaves extract in therapy of hyperglycemia.