Abstract
Mengkudu fruit contains scopoletin and temulawa k rhizome contains curcumin have been observed because they have strong antioxidant activity and they were used traditionally as antidiabetic. This research aimed to evaluate effect of antihyperglycemic and pancreas protection of juice combination of mengkudu fruit juice (MFJ) and temulawa k rhizome juice (TRJ) on diabetes rats which were inducted with streptozotocin (STZ). Rats were grouped into 7 groups, each of group consisting 5 rats. Each of group was treated accordingly for 28 days except for a normal group of rats. Rats taken blood from the plexus retroorbitalis for examination of blood glucose levels every week. On the last day, rats blood was examined for malondialdehyde (MDA) levels. After that the rats were turned off for examination of pancreatic morphological conditions. The results showed that diabetic rats given MFJ-TRJ combination juice experienced a significant decrease in blood glucose levels, a significant decrease in MDA levels and improvement pancreas morphology when compared with the negative control group. The conclusion of this research was giving combination juice of MFJ-TRJ juice can decreased blood glucose level, decreased MDA level and can improved pancreas morphology condition.
Highlights
Diabetes mellitus is a metabolic disease which is marked by a hyperglycemia condition
Hyperglycemia occurs due to pancreatic damage or failure of insulin secretion (Rathinam and Pari, 2016) causes interference of glucose metabolism, the degradation of the glucose entry into cell and increase of glucose release from liver into circulation (Huang et al, 2016)
Alkaloid in mengkudu fruit was able to revitalize and regenerate death cells until they are regenerated, it naturally can increase immune system, increase function of cells and fix damage cells in body that are caused of disease or aging process (Sayuti and Yenrina, 2015)
Summary
Diabetes mellitus is a metabolic disease which is marked by a hyperglycemia condition. Hyperglycemia occurs due to pancreatic damage or failure of insulin secretion (Rathinam and Pari, 2016) causes interference of glucose metabolism, the degradation of the glucose entry into cell and increase of glucose release from liver into circulation (Huang et al, 2016). This condition can lead to lipid metabolism failure (Kumar et al, 2016). Compound that has responsible toward pharmacology effect of temulawak rhizome is curcumin, a main chemical constituent in temulawak rhizome (Itokawa et al, 2008; Kant et al, 2014)
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