Abstract
Treatment of synthetic anti-diabetic drugs is costly and has high possibilities of unwanted effects such as nausea and jitters. Thus, there is a need to develop a drug of cheaper cost without, if not lesser, side effects. In this study, the in vivo hypoglycemic effect of partially purified Antidesma bunius fruit ethanolic extract was tested. Ethanolic fruit extracts were partially purified using liquid chromatography, obtaining four fractions (F1, F2, F3 and F4). These were administered orally (500 mg extract/kg body weight) to alloxan-induced diabetic female Balb/C mice to determine their hypoglycemic effects. Fasting blood glucose (FBG) levels were measured 5 days after alloxan injection, and on the 3rd, 7th, 10th, and the 14th day after treatment administration. Fractions F2 and F3 exhibited the highest blood glucose lowering activity, compared to the crude ethanolic extract and positive control. Phytochemical screening of F2 and F3 revealed the presence of tannins and indoles. These results demonstrate the partially purified A. bunius extract as a potential herbal drug candidate in diabetes therapy.
Highlights
Phytochemical screening of F2 and F3 revealed the presence of tannins and indoles. These results demonstrate the partially purified A. bunius extract as a potential herbal drug candidate in diabetes therapy
Diabetes is a syndrome characterized by a deranged carbohydrate metabolism that results from failure of pancreatic beta cells in maintaining adequate insulin secretion to prevent abnormally high blood glucose level called hyperglycemia (Rother, 2007)
The present study aims to demonstrate the hypoglycemic effects of partially purified A. bunius fruit extracts in alloxaninduced diabetic Balb/C mice, by comparing fasting blood glucose (FBG) levels before and after treatment
Summary
Diabetes is a syndrome characterized by a deranged carbohydrate metabolism that results from failure of pancreatic beta cells in maintaining adequate insulin secretion to prevent abnormally high blood glucose level called hyperglycemia (Rother, 2007). High blood glucose levels can damage nerves and blood vessels, resulting to neuropathies and vascular diseases. Diabetes is linked with other long term body malfunctions of the eyes, kidneys, nerves, heart and blood vessels, and health complications, including renal failure, sexual dysfunction, heart disease, stroke, and blindness (Kadhirvel et al, 2010). Compounds in fruits and beverages from A. bunius have been observed to possess nutritive values in human health, in healing of coronary heart disease (Hertog et al, 1997), reduce platelet aggregation (Knekt et al, 1996), and provide anti-carcinogenic protection (Stoclet et al, 2004)
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