Abstract
SUMMARYA brief review is given of recent claims that certain sulphonylurea compounds possess hypoglycMmic action. The results of clinical trials in the Diabetic and Metabolic Unit of the Alfred Hospital are presented. Clinical trials were undertaken on a selected group of 26 patients (18 females and eight males) and a satisfactory therapeutic response was obtained in 19 patients (13 females and six males). In the remaining patients treatment was regarded as a failure.The possible mode of action of sulphonylurea drugs is considered, and evidence is presented which suggests interference with transaminase systems in the liver. The conclusion is reached that these drugs do not act as substitutes for insulin, and that in view of side effects and the uncertain sequelM which may follow their prolonged administration, further work is necessary before they are made available for general use.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
