Abstract
This study investigated the antidiabetic and hypolipedemic action of Meyna spinosa leaf fractions. Effect of methanol, ethyl acetate and petroleum ether fraction (75 and 150 mg/kg p.o.) from M. spinosa leaf methanol extract was evaluated in high fat diet-alloxan induced type 2 diabetic rats after 21 days treatment. Glibenclimide (5 mg/kg), methanol and ethyl acetate fraction at 150 mg/kg exhibited 57.7, 63.4 and 53.8% reduction in serum glucose level after 21 days. Fractions demonstrated significant decrease in triglycerides, total cholesterol, low density lipid, very low density lipid, α-amylase level, and increase in body weight, high density lipid level in diabetic rats. Fractions showed significant (p<0.05) hypoglycemic effect in glucose loaded animals but not in normal rats. Petroleum ether fraction did not produced significant effect. Result validated the claim made by folk medicinal uses and confirmed the antidiabetic potential of methanol and ethyl acetate fraction of M. spinosa.
Highlights
Type 2 or non insulin dependent diabetes account for about 95% of all diagnosed cases of diabetes mellitus, and has a significant impact on the health, excellence and expectancy of life (Dewanjee et al, 2009)
2000 mg/kg dose was considered as ALD50 cut off the dose under Globally Harmonised Classification System (GHS) category 5
Fractions did not show any significant change in serum glucose level, while glibenclamide decreases serum glucose levels in normoglycemic rats
Summary
Type 2 or non insulin dependent diabetes account for about 95% of all diagnosed cases of diabetes mellitus, and has a significant impact on the health, excellence and expectancy of life (Dewanjee et al, 2009). Though several oral hypoglycemic agents are available, but most of these drugs possess different side effects. The hunt for a new therapeutic agent devoid of adverse effect originating from plants would be of interest (Kannur et al, 2006). (Rubiaceae) has been used in the treatment of hepatic disorder, gastrointestinal problems, skin infection, and as refrigerant, and abortifacient (Bora and Kumar, 2003; Dea et al, 2009; Mitra and Mukherjee, 2009). The boiled fruit extract is used to treat diabetes in Manipur, while fruit and leaf juice are recommended to cure diabetes by the tribes of Tripura, India (Khan and Yadava, 2010; Sen et al, 2011).
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