Abstract
A number of plants including Berberis aristata roots are considered effective as antidiabetic agents in ethnomedical practices. In this study effects of certain isolated fractions from root-bark of Berberis aristata on blood glucose levels were determined in normal and alloxan-diabetic rabbits. In normal rabbits, ethanolic fraction in 0.5, 1.0 and 1.5 g/kg produced significant decrease (P<0.05 or 0.001) at 8 and 12 hrs. Its acidified-basified fraction showed significant lowering of blood sugar at 2, 4, 8 and 12 hrs. The chloroform: methanol fraction also produced significant hypoglycaemic effect at these intervals. In alloxan-diabetic rabbits, ethanolic fraction in doses similar to normal animals produced significant decrease in blood glucose at 2, 4, 8 and 12 hrs. Also, acidified-basified fraction of the root-bark in 100 and 125mg/kg doses produced significant decrease in the levels at 2, 4 and 8 hrs.
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