Abstract
Introduction: Colorectal cancer (CRC) is the primary health problem worldwide. Besides survival, a significant problem in locally advanced rectal cancer is recurrence. Adding radiotherapy to surgery has been shown conclusively to improve local control for rectal cancer. Aim: To compare hypo fractionated short-course preoperative conformal radiotherapy versus long-course conventional preoperative chemoradiotherapy in the management of locally advanced rectal cancer. Materials and Methods: This prospective comparative study was conducted in 44 patients who grouped into ARM A (short course RT) for 22 patients and ARM B (long course Chemoradiotherapy) for 22 patients. Treatment protocol and follow up protocol was followed and the results were statistically analyzed and discussed. Results: Out of 44 patients, 22 patients had short-course radiotherapy (ARM A) and 22 patients had long course radio-chemotherapy (ARM B). In ARM A, 7 patients in stage T3NOMO, 2 patients in stage T3N1MO,9 patients in stage T4N0M0, 4 patients in stageT4N1M0,4patients had an interruption, 18 patients had no interruption, mean duration of diseases free survival is 354.59 125.86 days, 18 patients had a partial response, and 4 patients had stable diseases. In ARM B,5 patients in stage T3NOMO, 5 patients in stage T3N1MO, 7 patients in stages T4N0M0, 5 patients in stage T4N1M0, 14 patients had an interruption, 8 patients had no interruption, mean duration of diseases free survival is 414.27119.97 days, 19 patients had a partial response and 3 patients had stable diseases. Conclusion: Short-course neo-adjuvant radiotherapy using IMRT showed similar response rates and diseases free survival but less acute toxicity and short hospital stay when compared to the conventional long-course chemoradiotherapy. Keywords: Chemoradiotherapy, Preoperative treatment, Rectal cancer.
Highlights
Colorectal cancer (CRC) is the primary health problem worldwide
Aim Our study aims to compare hypo fractionated shortcourse preoperative conformal radiotherapy versus longcourse conventional preoperative chemoradiotherapy in the management of locally advanced rectal cancer
After getting written consent form, eligible patients were randomly assigned to receive either short-course radiotherapy in ARM A and conventional long-course Chemoradiotherapy in ARM B
Summary
Colorectal cancer (CRC) is the primary health problem worldwide. Aim: To compare hypo fractionated short-course preoperative conformal radiotherapy versus long-course conventional preoperative chemoradiotherapy in the management of locally advanced rectal cancer. Conclusion: Short-course neo-adjuvant radiotherapy using IMRT showed similar response rates and diseases free survival but less acute toxicity and short hospital stay when compared to the conventional long-course chemoradiotherapy. Colorectal cancer (CRC) is a leading health problem worldwide. Colorectal cancer is the second most common cancer in women and the third most common cancer in men worldwide. Colorectal cancer has become the third most common cancer worldwide preceded by only lung and breast cancer, with nearly 14 million new cases of all sex in the year 2012. Mortality from colorectal cancer is estimated at nearly 4,50,000 per year.[4]
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