Hypofractionated radiosurgery treatment of skull base meningiomas

Abstract

The study objective is to analyze the results of hypofractionated radiosurgery treatment of patients with skull base meningiomas with a complex topographic and anatomical location using the Gamma Knife device. Materials and methods. The study was based on the results of examination and radiosurgery treatment of 36 patients (13 male, 23 female) with skull base meningiomas. Mean age (Me[Q25;Q75]) at the period of the treatment was 65 [42;88]. All patients underwent triple treatment in the dose hypofractionation mode with an interfractional interval of 1-2 days. The follow-up duration was 6-36 months. Results and discussion. All patients underwent control magnetic resonance imaging, which demonstrated tumor growth stabilization or decrease. There were no signs of continued growth and post-radiation reactions of neurotoxicity. The neuropathy of the cranial nerves during the control observation time remained at the preoperative level. The relative decrease in tumor size occurred faster in the group of patients with a tumor volume of more than 10 cm³. Conclusion. Hypofractionated stereotactic radiosurgery is safe and highly effective. High-level tumor control and a low incidence of post-radiation reactions make it possible to use the indicated method in the treatment of skull base meningiomas, involving the anterior parts of the visual analyzer and other radiosensitive structures.