Abstract
Hypodontia, or tooth agenesis, is the most prevalent craniofacial malformation in humans. It may occur as part of a recognised genetic syndrome or as a nonsyndromic isolated trait. Excluding third molars, the reported prevalence of hypodontia ranges from 1.6 to 6.9%, depending on the population studied. Most affected individuals lack only one or two teeth, with permanent second premolars and upper lateral incisors the most likely to be missing. Both environmental and genetic factors are involved in the aetiology of hypodontia, with the latter playing a more significant role. Hypodontia individuals often present a significant clinical challenge for orthodontists because, in a number of cases, the treatment time is prolonged and the treatment outcome may be compromised. Hence, the identification of genetic and environmental factors may be particularly useful in the early prediction of this condition and the development of prevention strategies and novel treatments in the future.
Highlights
Hypodontia is the most prevalent dentofacial malformation in humans [1]
Its phenotypic presentation is varied in terms of severity and, as a result, various terms have been used to describe it. These terms include “congenitally missing teeth,” “tooth agenesis,” “hypodontia,” “oligodontia,” and “anodontia.” The term “congenitally missing teeth” is challenging because tooth development is completed after birth, so that the presence of most tooth germs can be proved only during childhood [4,5,6]
Tooth agenesis and hypodontia are the preferred terms in this work, with the latter term limited to missing teeth other than third molars
Summary
Hypodontia is the most prevalent dentofacial malformation in humans [1]. It may occur as part of a recognised genetic syndrome or as a nonsyndromic isolated trait [2]. Its phenotypic presentation is varied in terms of severity and, as a result, various terms have been used to describe it. These terms include “congenitally missing teeth,” “tooth agenesis,” “hypodontia,” “oligodontia,” and “anodontia.” The term “congenitally missing teeth” is challenging because tooth development is completed after birth, so that the presence of most tooth germs can be proved only during childhood [4,5,6]. On the other hand, refers directly to the developmental failure of a tooth. Other terms, such as hypodontia, are more suitable for classifying the type of tooth agenesis present and may be more appropriate in this context [7]. Tooth agenesis and hypodontia are the preferred terms in this work, with the latter term limited to missing teeth other than third molars
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