Abstract
Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are neurodevelopmental disorders caused by deletion or mutation within maternal or paternal chromosome 15q11–q13, respectively. Patients with AS are poor sleepers and patients with PWS often exhibit excessive daytime sleepiness. Because of reports of low CSF hypocretin-1 levels in PWS patients with excessive daytime sleepiness, we decided to examine hypocretin-1 levels in the CSF of two AS patients with sleep abnormalities. CSF hypocretin-1 levels of our two AS patients were in the lower border of the normal range, which is similar to CSF hypocretin-1 levels found in PWS patients with excessive daytime sleepiness. The role of hypocretin-1 in the regulation of sleep in both syndromes remains undetermined.
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