Abstract
Abundant circumstantial evidence has shown that chronic hyperlipidemia is one of the major clinical manifestations of ischemic heart disease (IHD) and many drugs have been developed which reduce serum lipids. Clofibrate has been one of the most effective drugs used for lowering serum cholesterol and reducing the morbidity of patients suffering from IHD. However, prolonged treatment with clofibrate has been reported to cause higher incidences of gastrointestinal disorders and to induce cholesterol oversaturation of bile. These deleterious side effects have resulted in a restriction of the use of clofibrate and new drugs exerting selective and non toxic hypolipidemic actions have been intensively researched. (Dichloro-2,4 phenoxy)-2 propionic acid, structurally-related to fibrates with an asymmetric carbon is well know for its herbicide effectiveness. However, nobody has investigated its possible effect on cholesterol /sup 14/C-acetate metabolism. The purpose of this study is to explore the effects of this compound on cholesterol metabolism in the rat and to compare them with those of clofibrate. It is the first time that a low concentration (0.04 mmole) of this well-known pesticide has been shown to lower plasma cholesterol when added to the diet.
Published Version
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