Abstract
BackgroundCholesterol has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence about crucial requirement of neuron membrane cholesterol in the organization and function of the 5-HT1A serotonin receptor. For this, low cholesterol level has been reported to be associated with depression and suicidality. However there have been inconsistent reports about this finding and the exact relationship between these factors remains controversial. Therefore, we investigated the link between serum cholesterol and its fractions with depression disorder and suicide attempt in 467 adult subjects in Mexican mestizo population.MethodsPlasma levels of total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) were determined in 261 MDD patients meeting the DSM-5 criteria for major depressive disorder (MDD), 59 of whom had undergone an episode of suicide attempt, and 206 healthy controls.ResultsA significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglyceride serum levels was observed in the groups of MDD patients and suicide attempt compared to those without suicidal behavior (p < 0.05). After adjusting for covariates, lower cholesterol levels were significantly associated with MDD (OR 4.229 CI 95% 2.555 – 7.000, p<.001) and suicide attempt (OR 5.540 CI 95% 2.825 – 10.866, p<.001)ConclusionsThese results support the hypothesis that lower levels of cholesterol are associated with mood disorders like MDD and suicidal behavior. More mechanistic studies are needed to further explain this association.
Highlights
Cholesterol has been associated as a risk factor for cardiovascular disease
Roughly 60% of all suicides occur in the context of depressive disorders [7, 8] it is still challenging for clinicians to predict suicide risk in patients with depression
Study population After the approval of protocol by Research and Ethics Committee of the General Hospital 450 (No 12/03062015), a case-control study was conducted with 261 major depressive disorder (MDD) adult patients, 59 of these had a recent episode of suicide attempt and 206 healthy adult volunteer controls of both genders; all subjects provided informed consent
Summary
Cholesterol has been associated as a risk factor for cardiovascular disease. Recently, there is growing evidence about crucial requirement of neuron membrane cholesterol in the organization and function of the 5-HT1A serotonin receptor. Suicide is one of the most disastrous outcomes of psychiatric disorders [1] It is a significant public health problem and is one of the leading causes of death worldwide [2,3,4]. Roughly 60% of all suicides occur in the context of depressive disorders [7, 8] it is still challenging for clinicians to predict suicide risk in patients with depression. For this reason, increased attention has been paid to potential biomarkers for suicide in patients with major depressive disorder (MDD) and suicidal behavior [1, 9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
