Abstract
A group of rabbits were given in sequence a laboratory stock diet (I), a semi-purified diet containing 25% casein (II), and a similar diet in which soya bean meal replaced casein (III). On changing from diet I to II, plasma cholesterol rose fourfold after 16 weeks, but fell 50% after 12 weeks on changing from diet II to III. Replacement of casein with soya bean meal in the semi-purified diet caused an increased faecal excretion of sterols but not of bile acids. The ratio of cholesterol ingested/cholesterol and metabolites excreted, fell from a mean of 1.6 to 0.6. It is concluded that the hypocholesterolaemic effect of soya bean meal is probably due to its action in increasing the excretion of faecal neutral sterols.
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