Abstract
IntroductionHypocellular variants of acute myeloid leukemia are very rare and almost always occur in old aged patients. In contrast, hypocellular acute lymphoblastic leukemia usually occurs in children.Case presentationWe report two Indian patients with hypocellular acute myeloid leukemia, a 32-year-old woman and a 13-year-old boy. Interestingly, one of the patients also showed bone marrow necrosis.ConclusionHypocellular acute myeloid leukemia is a rare entity and can affect young individuals. It can be considered as a rare cause of bone marrow necrosis.
Highlights
Hypocellular variants of acute myeloid leukemia are very rare and almost always occur in old aged patients
Hypocellular acute myeloid leukemia is a rare entity and can affect young individuals. It can be considered as a rare cause of bone marrow necrosis
This paper describes two rare cases of hypocellular acute myeloid leukemia (AML) in young patients (a 32-year-old woman and a 13-year-old boy)
Summary
The infrequent occurrence of hypocellularity at presentation of acute leukemia has been widely recognized. This paper describes two rare cases of hypocellular acute myeloid leukemia (AML) in young patients (a 32-year-old woman and a 13-year-old boy). Journal of Medical Case Reports 2009, 3:27 http://www.jmedicalcasereports.com/content/3/1/27 hematopoietic elements were markedly diminished Based on all these features, a tentative diagnosis of acute myeloid leukemia French-AmericanBritish (FAB) subtype M1 (AML-M1) was made. Case 2 A 13-year-old Indian boy presented after a 10-day episode of right submandibular swelling On examination, he had severe pallor and an enlarged hot and tender right submandibular gland. Peripheral blood smear examination revealed 40% blasts with low platelets These blasts were of intermediate size, had moderate cytoplasm, opened-up nuclear chromatin and 1 to 4 prominent nucleoli.
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