HYPOALBUMINEMIA–A RISK FACTOR IN COVID 19 PATIENTS ADMITTED AT ACPM MEDICAL COLLEGE DURING SECOND WAVE OF EPIDEMIC.

Abstract

Background: Hypoalbuminemia is amongst the most frequently observed laboratory abnormalities in patients with SARS-CoV-2 infection. Profound hypoalbuminemia seen in COVID-19 may be due to intense systemic inammation. Hypoalbuminemia is common in many inammatory diseases. Present study was aimed to study the value of hypoalbuminemia on admission as a predictor of mortality and adverse events in COVID 19 patient. Present study Material and Methods: was single-center, Retrospective Crosssectional study, conducted from case records of patients with clinical manifestations like fever and pulmonary symptoms and RT-PCR positive for SARS-CoV-2. In present study 100 case-records satisfying study criteria were considere Results: d for this study. The male predominant was observed 63(63.0 %) than female 37(37.0%). The mean age of present study patients were 62.37 ± 14.02 year. Majority of 69% of patients required respiratory support during COVID-19. Majority cases had moderate COVID (50 %) as compared to severe COVID (31.82 %) & mild COVID (18.18 %). Mortality was 14.77 %. The mean Serum Albumin level was signicantly lower in Severe COVID cases 2.09 ± 0.94 g/dl as compared to Moderate 3.01 ± 1.03 g/dl & Mild 4.93 ± 1.59 g/dl COVID disease severity. There was statistical signicant difference in mean Serum Albumin in Disease Severity of COVID-19 (p=0.001). The mean Serum Albumin level of died patients was 1.89±0.95 g/dl, which was comparatively lower as compared to live (discharged) patients 3.87±1.78 g/dl. There was statistical signicant difference in mean Serum Albumin level in clinical outcome of COVID-19 patients (p<0.001). The low albumin Conclusion: is associated with disease severity and poor outcomes in terms of worse respiratory failure due to alveolar endothelial damage in COVID-19.