Hypoadiponectinemia Correlates With Metabolic Syndrome in Kidney Transplantation Patients

Abstract

Serum adiponectin values correlate inversely with the presence of metabolic syndrome (MS). This study was undertaken to evaluate the relationship between MS and fasting serum adiponectin concentrations in 55 kidney transplantation patients. MS and its components were defined using the diagnostic criteria of the International Diabetes Federation. Thirteen subjects (23.6%) with MS showed negative correlations with adiponectin levels ( P = .035), which also negatively correlated with a number of MS criteria ( P = .015). Univariate linear regression analysis showed, serum adiponectin values to negatively correlate with waist circumference ( r = −0.367; P = .006), body mass index (r = −0.306; P = .023), and body fat mass (r = −0.373; P = .005). Multivariate forward stepwise linear regression analysis of the significant variables revealed that body fat mass ( R 2 change = 0.139; P = .035) and waist circumference ( R 2 change = 0.067; P = .041) were independent predictors of fasting serum adiponectin concentrations. Thus, serum adiponectin concentrations correlated inversely with MS. Body fat mass and waist circumference were independent predictors of serum adiponectin values in kidney transplant patients.