Hypoadiponectinemia and high TG/HDLc ratio as risk markers of insulin resistance in obese PCOS women

Abstract

PCOS is characterized by reduced insulin sensitivity and cardiovascular risk. Adiponectin, plays a major role that favours insulin sensitivity and possess vaso-protective function. TG:HDLc ratio, an inexpensive tool predicts insulin resistance. Study aims to relate adiponectin and TG:HDLc ratio with insulin resistance in obese infertile women with PCOS. In this cross-sectional observational study, as per Rotterdam’s criteria 129 obese PCOS women with BMI ≥ 23 were compared with 110 aged matched controls with BMI < 23. Cardiac risk ratio-1 (TC:HDLc) and 2 (LDLc:HDLc) were calculated. Insulin resistance represented as HOMA-IR, HOMA-adiponectin and triglyceride HDLc ratio (TG:HDLc) were calculated. Adiponectin levels was significantly lowered and pearson correlation showed negative correlation with TC, TGL, LDL, TC:HDLc, LDL:HDLc and TGL:HDLc; whereas strongly positive correlation with HDLc. TG:HDL ratio was significantly elevated (4.23 ± 0.81) in 64% of PCOS women and were insulin resistant as divulged by the elevation of HOMA-IR and HOMA-adiponectin. Simple linear regression analysis of adiponectin with TGL:HDLc (R2 = 0.68) LDLc (R2 = 0.84) HDLc (R2 = 0.86) revealed the association between variables. Adiponectin and TGL:HDLc ratio are useful markers of insulin resistance that relates to the threat of cardiovascular diseases in obese women with PCOS.