Hypoactive sexual desire disorder (HSDD) in women with and without comorbid conditions

Abstract

OBJECTIVE: To describe clinical characteristics & comorbid conditions of women with commercial insurance diagnosed with HSDD.DESIGN: Retrospective U.S. claims database analysis.MATERIALS AND METHODS: The Marketscan® Commercial Database of adjudicated insurance claims was used to identify women aged 18-64 diagnosed with HSDD (ICD-9 code: 302.71) from 1/98-9/06 (prior to most studies of HSDD). Clinical characteristics & comorbid conditions associated with sexual dysfunction were examined in the year prior to diagnosis.RESULTS: 2,870 women were diagnosed with HSDD, 70% of whom were between the ages of 18 & 49 (younger women) while 30% were between the ages of 50 & 64 (older women). In the 12 months prior to diagnosis with HSDD, younger women were more likely than older women to have had gynecological surgery (3.6% vs. 1.7%, p=0.0064), or fill a prescription for birth control (25.4% vs. 4.1%, p<0.0001). Older women were more likely to have non-reproductive associated conditions that could affect sexual dysfunction including diabetes (5.0% vs. 1.9%, p<0.0001), thyroid abnormality (11.2% vs. 7.0%, p=0.0002), cancer or history of cancer (7.8% vs. 1.8%, p<0.0001). Approximately two-thirds of women in each age group had at least one condition possibly correlated with sexual dysfunction. Deyo Charlson Comorbitity scores indicated that women without correlates of sexual dysfunction were significantly healthier relative to those with at least one correlate (0.06 vs. 0.18, p<0.0001 in younger women & 0.07 vs. 0.41, p<0.0001 in older women).CONCLUSIONS: Approximately one-third of women with HSDD have no diagnosed or treated medical conditions known to affect sexual functioning. For these women, HSDD may be their only medical diagnosis. Of the women with comorbid conditions, younger women were more likely to have conditions directly affecting their reproductive systems, while older women were more likely to have non-reproductive conditions. OBJECTIVE: To describe clinical characteristics & comorbid conditions of women with commercial insurance diagnosed with HSDD. DESIGN: Retrospective U.S. claims database analysis. MATERIALS AND METHODS: The Marketscan® Commercial Database of adjudicated insurance claims was used to identify women aged 18-64 diagnosed with HSDD (ICD-9 code: 302.71) from 1/98-9/06 (prior to most studies of HSDD). Clinical characteristics & comorbid conditions associated with sexual dysfunction were examined in the year prior to diagnosis. RESULTS: 2,870 women were diagnosed with HSDD, 70% of whom were between the ages of 18 & 49 (younger women) while 30% were between the ages of 50 & 64 (older women). In the 12 months prior to diagnosis with HSDD, younger women were more likely than older women to have had gynecological surgery (3.6% vs. 1.7%, p=0.0064), or fill a prescription for birth control (25.4% vs. 4.1%, p<0.0001). Older women were more likely to have non-reproductive associated conditions that could affect sexual dysfunction including diabetes (5.0% vs. 1.9%, p<0.0001), thyroid abnormality (11.2% vs. 7.0%, p=0.0002), cancer or history of cancer (7.8% vs. 1.8%, p<0.0001). Approximately two-thirds of women in each age group had at least one condition possibly correlated with sexual dysfunction. Deyo Charlson Comorbitity scores indicated that women without correlates of sexual dysfunction were significantly healthier relative to those with at least one correlate (0.06 vs. 0.18, p<0.0001 in younger women & 0.07 vs. 0.41, p<0.0001 in older women). CONCLUSIONS: Approximately one-third of women with HSDD have no diagnosed or treated medical conditions known to affect sexual functioning. For these women, HSDD may be their only medical diagnosis. Of the women with comorbid conditions, younger women were more likely to have conditions directly affecting their reproductive systems, while older women were more likely to have non-reproductive conditions.