Abstract
F23 This study was planned to compare the safety and efficacy of a hypo-osmolar oral rehydration solution (HORS) (245 mmol/litre) with the World Health Organization oral rehydration solution (WHO ORS) in acute non-cholera diarrhea. This is a preliminary report of an ongoing study, with a planned population of one hundred. So far children, aged 3 to 60 months, admitted in the Diarrhea Treatment and Training Unit (DTTU) were included and randomly assigned to receive H-ORS or WHO-ORS. Intake and output were measured every 4 hour. The mean purge rate of the children receiving HORS was significantly lower (95% CI -5.05 to -0.55) than that of the WHO-ORS group. The duration of diarrhea (95% Cl -24.1 to 3.7), ORS consumed (95% CI -1724.7 to 823.0), caloric intake (95% CI -25.4 to 8.2), serum sodium levels (95% Cl -4.6 to 1.7), urine output (95% CI [email protected] to 53.5) and weight gain (95% CI -2.2 to 1.7 ′ i were similar in the two groups. Hyponatremia was not documented in any of the cases. The relative risk of the need for intravenous fluids and persistence of dehydration beyond 24 hours was also comparable. The prefatory data shows that reduced osmolarity ORS is associated with a lower purge rate in acute non-cholera diarrhea without predisposing to hyponatremia.
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