Abstract
Partially purified pregnant mare urine extracts when injected intraperitoneally into rats in a dose of 1.1–1.2 g/kg induced hypnosis both at room temperature and at an elevated ambient temperature. Furthermore, doses of extract which induced hypnosis caused a profound fall of rectal temperature (6–8°C). The extract potentiated the hypnotic effect of hexobarbital both at room and elevated ambient temperatures. Pretreatment with graded doses of picrotoxin, metrazol and nikethamide antagonized the hypnotic but not the hypothermic effect of the extract. On the other hand amphetamine pretreatment significantly decreased or reversed extract induced hypothermia. Pretreatment with iproniazid potentiated while iproniazid + alpha-methyl-meta-tyrosine pretreatment antagonized extract-induced hypothermia.
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