Abstract
Measurement of serum cobalamin (vitamin B12) is routinely used in Endocrinology/Metabolism in order to diagnose or rule out a suspected Cobalamin deficiency. Hypervitaminemia B12 or high serum level of cobalamin B12 is a clinical underestimated abnormality. A high fraction of patients have high cobalamin levels and no consensus exists regarding the clinical implications for this endocrine marker, which can be involved in serious medical situations like solid neoplasms, hepatopathy, hemopathy, renal failure, and also in case of functional deficiency. We describe four clinical cases illustrating this problem, and possible links between Hypervitaminia B12 and malignant diseases, potentially engaging the prognosis.
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