Abstract
Using a PCR based method, we determined hypervariable markers of the Thyroid Peroxidase gene (TPO-VNTR markers) by size classification of alleles in a total of 146 blood samples (76 from Sicily and 70 from Lombardy, South and North Italy respectively). A total of 22 alleles were identified. They varied in size from 6 (0.4 Kbp) to 27 (1.5 Kbp) repeats and showed a unimodal distribution (peak at 15 repeat number). Data were compared with those previously obtained in two other Italian samples from Calabria (South Italy) and from Sardinia. Heterogeneity G tests on allele frequency distributions led to the following conclusions: 1) as observerd for the majority of the known polymorphisms, the Sardinian sample is clearly distinguishable from all the others; 2) although on the whole no significant heterogeneity emerges from the comparison between southern and northern Italians, certain allelic frequencies are able to distinguish between groups.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
