Hyperuricemia associated with the treatment of acute leukemia.

Abstract

Article1 September 1957HYPERURICEMIA ASSOCIATED WITH THE TREATMENT OF ACUTE LEUKEMIAG. LENNARD GOLD, M.D., RICHARD D. FRITZ, M.D.G. LENNARD GOLD, M.D.Search for more papers by this author, RICHARD D. FRITZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-3-428 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElevations of serum and urinary concentrations of uric acid have been described in acute leukemia.1, 2 It is also known that, with therapy, urate excretion may rise.3, 4, 5, 6 Recently the authors have had an opportunity to view two patients who showed a marked degree of hyperuricemia concomitant with therapy of their acute lymphocytic leukemia. The authors thought that a review of these cases might point out a hazard in treating these patients.CASE REPORTSCase 1. A 50 year old white female housewife had been well until the winter of 1954, when she developed unusual fatigue and a...Bibliography1. Wintrobe MM: Clinical hematology, 3d Ed., 1951, Lea and Febiger, Philadelphia. Google Scholar2. Broehner-Mortensen K: The uric acid content in blood and urine in health and disease, Medicine 19: 161, 1940. CrossrefGoogle Scholar3. JugenburgTschotschia AK: Neue Ergebnisse zum Verständnis des Leukämieverlaufes, Strahlentherapie 41: 86, 1931. Google Scholar4. Merrill D: Uremia following x-ray therapy in leukemia, New England J. Med. 222: 94, 1940. CrossrefGoogle Scholar5. BedrnaPolcak JJ: Akuter Harnleiterverschluss nach Bestrahlung chronischer Leukämien mit Röntgenstrahlen, Med. Klin. 25: 1700, 1929. Google Scholar6. KravitzDiamondCraver SCHDLF: Uremia complicating leukemia chemotherapy, J. A. M. A. 146: 1595, 1951. CrossrefMedlineGoogle Scholar7. PhillipsThierschBendich FSJBA: Adenine intoxication in relation to in vivo formation and deposition of 2,8-dioxyadenine in renal tubules, J. Pharmacol. and Exper. Therap. 104: 20, 1952. MedlineGoogle Scholar8. BurchenalWaringEllisonReilly JHGBRRHC: A simple method for determination of levels of amethopterin in blood and urine, Proc. Soc. Exper. Biol. and Med. 78: 603, 1951. CrossrefMedlineGoogle Scholar9. SandbergCartwrightWintrobe AAGEMM: Studies on leukemia. I. Uric acid excretion, Blood 11: 154, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication November 27, 1956.From the General Medicine Branch, Acute Leukemia Section, National Cancer Institute, Bethesda, Maryland.Requests for reprints should be addressed to Richard D. Fritz, M.D., National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland. 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C.Acute leukemia treated by irradiation and marrow transplantExcessive Uric Acid Production in the Human induced by 2-Ethylamino-1,3,4-thiadiazoleDie Pathomorphologie der Nierenausscheidung 1 September 1957Volume 47, Issue 3Page: 428-434KeywordsAdrenocorticotropic hormoneAttentionExcretionFatigueNucleic acidsPrecursor cellsUreaUric acid Issue Published: 1 September 1957 PDF downloadLoading ...