Abstract
Background: The clinical significance of uric acid (UA) in patients with chronic kidney disease (CKD) has never been elucidated in detail. Objectives: The aim of this study was to elucidate the predictive value of hyperuricemia (HU) in relation to kidney disease progression in CKD patients. Methods: We reviewed data obtained from 201 CKD patients. Renal outcome was assessed by performing the Kaplan-Meier and Cox proportional hazard regression models. The renal outcomes of CKD patients with and without HU were compared by using a propensity score-matched cohort. Results: The results of a multivariate Cox regression analysis showed that HU (UA ≥ 7.1 mg/dL) (P = 0.001), diabetes mellitus (P = 0.003), and a high urine albumin-to-creatinine ratio (P = 0.0005) were significantly associated with a ≥50% eGFR decline or ESRD. The serum UA values were positively correlated with mean blood pressure (P = 0.007), visceral fat area (P = 0.0003), and maximum carotid intima-media thickness (P = 0.0003). The Kaplan-Meier analysis in the propensity score-matched cohort indicated that the renal survival rate of the group of CKD patients with HU was significantly lower than that of the group without HU (log rank, P < 0.0001), even after complete adjustment for the eGFR. Conclusion: The results of this study suggest that the serum UA value is a predictor of CKD progression.
Highlights
Chronic kidney disease (CKD) is affected by multiple risk factors for disease progression [1] [2], and it is extremely important to identify risk factors for the acceleration of the chronic kidney disease (CKD) progression
The results of a multivariate Cox regression analysis showed that HU (UA ≥ 7.1 mg/dL) (P = 0.001), diabetes mellitus (P = 0.003), and a high urine albumin-to-creatinine ratio (P = 0.0005) were significantly associated with a ≥50% estimated glomerular filtration rate (eGFR) decline or ESRD
The results showed significant associations between HU [hazard ratio (HR) = 8.07, 95% confidence intervals (CIs) (2.25 - 33.3), P = 0.001], diabetes mellitus (HR = 8.61, P = 0.003), and urine albumin-to-creatinine ratio (UACR) (HR = 1.02, P = 0.0005) and a ≥50% eGFR decline or ESRD (Table 2(a)), and sex-stratified analysis yielded similar results
Summary
Chronic kidney disease (CKD) is affected by multiple risk factors for disease progression [1] [2], and it is extremely important to identify risk factors for the acceleration of the CKD progression. The aim of the present study was to elucidate the predictive value of hyperuricemia (HU) in relation to kidney disease progression in CKD patients. The clinical significance of uric acid (UA) in patients with chronic kidney disease (CKD) has never been elucidated in detail. Objectives: The aim of this study was to elucidate the predictive value of hyperuricemia (HU) in relation to kidney disease progression in CKD patients. The renal outcomes of CKD patients with and without HU were compared by using a propensity score-matched cohort. The Kaplan-Meier analysis in the propensity score-matched cohort indicated that the renal survival rate of the group of CKD patients with HU was significantly lower than that of the group without HU (log rank, P < 0.0001), even after complete adjustment for the eGFR. Conclusion: The results of this study suggest that the serum UA value is a predictor of CKD progression
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
