Abstract
BackgroundMetabolic syndrome is a cluster of the most dangerous heart attack risk factors such as diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure. Hyperuricemia is a condition in which the serum uric acid concentration is greater than 5.5 mg per deciliter for child and greater than 7.2 and 6.0 mg per deciliters for male and female adults respectively.MethodsA cross-sectional study was conducted to determine the magnitude of hyperuricemia and associated factors among type 2 diabetes mellitus patients at Hawassa Comprehensive Specialized Hospital (HCSH) from February 28 to May 30 /2017. A random sampling technique was used to include 319 study subjects and a signed consent had been provided by each study subject before running any data collection. An interviewer administered structured questionnaire was used to collect socio-demographic and some clinically useful data. In addition to this, we reviewed the records of the study subjects to obtain other useful clinical data. Five milliliter blood specimen was collected from each study subjects after overnight fasting. A25TM Bio-System Random Access chemistry analyzer was used for blood sample analysis. All data were checked visually, coded and entered into epi-data version 3.4 and statistical analysis was performed using SPSS version 20.0 software. Bi-variate and multivariate logistic regressions were used to determine the association between explanatory and the outcome variables.ResultsThe prevalence of hyperuricemia and metabolic syndrome among type 2 diabetic patients in the study area were 33.8%(n = 106) and 70.1% (n = 220) respectively. Having age greater or equal to 45 years (AOR: 1.9, CI: 1.-3.2, P value =0.015) and having metabolic syndrome (AOR: 2.6, CI: 1.5–4.7, P value = 0.001) were the determinant variables for hyperuricemia among type 2 diabetic patients.ConclusionThere was high prevalence of hyperuricemia among type 2 diabetic patients with high prevalence of metabolic syndrome. Therefore, regular health information about life style modification, early diagnosis and treatment for hyperuricemia and metabolic syndrome are essential to reduce hyperuricemia and metabolic syndrome in type 2 diabetic patients.
Highlights
Metabolic syndrome is a cluster of the most dangerous heart attack risk factors such as diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure
The prevalence of hyperuricemia was higher among study subjects with non-family history of diabetes as compared to study subjects with family history of diabetes (25.2% versus 8.6% respectively)
Higher serum uric acid concentration was determined among Type 2 diabetes mellitus (T2DM) patients with Metabolic syndrome (MetS) and among those with no history of regular exercise (27.7% and 24.8% respectively) as compared to those study subjects without MetS and with history of regular exercise (6.0% and 8.9% respectively)
Summary
Metabolic syndrome is a cluster of the most dangerous heart attack risk factors such as diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure. Metabolic syndrome (MetS) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease (CVD) and diabetes mellitus. Hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), hyperglycemia, and hypertension are the major risk factors for development of metabolic syndrome [4,5,6,7]. Insulin resistance is correlated with risk factors of MetS such as dyslipidemia and hypertension. Insulin resistance has a great impact on lipoprotein metabolism and it is associated with an increased level of triglycerides and reduced HDL-C in the blood. Some studies had revealed that there is a statistically significant association between hyperuricemia and insulin resistance was well demonstrated [8,9,10,11,12]
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