Abstract
The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p<0.0001). There was an association between Hyperuricemia and left ventricular hypertrophy (x2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.
Highlights
Systemic hypertension (HT) is a common disease globally, with populations of African descent being most prone to its complications [1,2,3,4,5]
HT contributes to both cardiovascular and cerebrovascular endpoints, including heart failure (HF), myocardial infarction (MI) and stroke and it accounts for 16.5% of all deaths including 51% of deaths due to strokes and 45% of deaths due to coronary artery disease (CAD) [7, 8]
The objective of the study was to determine the prevalence of HU and evaluate its correlation with target organ damage (TOD) and electrocardiographic (ECG) changes in newly diagnosed adult Nigerian hypertensive patients
Summary
Systemic hypertension (HT) is a common disease globally, with populations of African descent being most prone to its complications [1,2,3,4,5]. In 2010, HT was the commonest of the three leading risk factors for global disease burden [6]. The reason for the enormous burden of HT has been reported in numerous studies, showing that it is strongly associated with overall cardiovascular risk [6,7,8]. In Nigeria, studies have reported prevalence varying from 12% to 36.6% [9,10,11,12,13]. African American adults have among the highest prevalence of HT (44%) in the world [18]. The Framingham and other epidemiological surveys as well as experimental studies have shown that hyperuricemia (HU) significantly increases the risk for cardiovascular disease
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