Abstract
BackgroundWallerian degeneration (WD) can occur in different projecting systems, such as corticospinal tract, dentate-rubro-olivary pathway, and corticopontocerebellar tract. However, the co-occurrence of hypertrophic olivary degeneration (HOD) and middle cerebellar peduncles (MCPs) degeneration secondary to unilateral pontine infarction in a single patient is extremely rare.Case presentationA 71-year-old man presented with acute onset of dizzness, slurred speech, and right-sided weakness. On the next day, his previous neurologic deficits deteriorated. Brain magnetic resonance imaging (MRI) revealed acute ischemic stroke of the left pons. After treatment with thrombolysis, antiplatelets, and rehabilitation training, his speaking and motor function improved moderately. At the 3-month follow-up, the MRI showed hyperintensity in the left medulla oblongata and bilateral MCPs on T2-weighted and FLAIR images, suggesting HOD as well as MCPs degeneration.ConclusionsIt is of great importance for us to know the anatomic knowledge of dentate-rubro-olivary and corticopontocerebellar pathways.
Highlights
Wallerian degeneration (WD) can occur in different projecting systems, such as corticospinal tract, dentate-rubro-olivary pathway, and corticopontocerebellar tract
It is of great importance for us to know the anatomic knowledge of dentate-rubro-olivary and corticopontocerebellar pathways
WD of the middle cerebellar peduncles (MCPs) following pontine infarction has been rarely depicted on conventional magnetic resonance imaging (MRI) studies
Summary
Wallerian degeneration (WD) can occur in different projecting systems, such as corticospinal tract, dentate-rubro-olivary pathway, and corticopontocerebellar tract. Conclusions: It is of great importance for us to know the anatomic knowledge of dentate-rubro-olivary and corticopontocerebellar pathways. Apart from corticospinal tract, WD can occur in other projecting systems, including corticopontocerebellar tract, dentate-rubro-olivary pathway, posterior column of the spinal cord, corpus callosum, limbic circuit, and optic pathway [2]. WD of the middle cerebellar peduncles (MCPs) following pontine infarction has been rarely depicted on conventional magnetic resonance imaging (MRI) studies.
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