Abstract
The allylisopropylacetamide (AIA) administration to rats causes in three days a peculiar type of hypertriglyceridemia associated with low plasma free fatty acids. This experimental condition represents a rapid test for screening the drug activity on fatty acid biosynthesis “in vivo”. The nicotinic acid administration lowers the free fatty acid (FFA) levels in normal and in AIA-treated rats; and the triglyceride values more in the second than in the first group of animals. Particularly nicotinic acid is much more active in decreasing the triglyceride levels than in lowering the FFA values in AIA-treated rats. The mechanism of action of AIA and nicotinic acid is discussed.
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