Hypertriglyceridemia: An Independent Risk Factor of Chronic Kidney Disease in Taiwanese Adults

Abstract

BackgroundThe prevalence and incidence of chronic kidney disease (CKD) are relatively high in Taiwanese patients than in patients of other countries, particularly in the older age groups. Dyslipidemia in patients with CKD has been recognized as a risk factor for disease progression but the role of triglycerides (TGs) remains controversial. With this regard, we evaluated the effects of hypertriglyceridemia on renal function in Taiwanese adults (aged ≥40 years). MethodsFrom January 2002 to December 2006, we conducted a community-based medical screening program in Chiayi County with 18,422 subjects (aged ≥40 years). The CKD was defined as an estimated glomerular filtration rate of <60mL min 1.73 m2. Age, body mass index, systolic blood pressure, fasting plasma glucose, and serum total cholesterol were considered as potential confounders. ResultThe CKD was prevalent in 24.2% of the middle-aged and elderly population. By using multiple logistic regression models, we determined that old age and elevated levels of body mass index, systolic blood pressure, fasting plasma glucose, and cholesterol were associated with CKD. The adjusted odds ratios of CKD in participants with serum TG ≧200mg/dL was 1.901 (95% confidence interval: 1.07–3.36; P < 0.05) and in participants with serum TG > 500mg/dL it increased to 2.205 (1.33–3.64, P < 0.05). ConclusionHypertriglyceridemia is an independent risk factor for CKD in Taiwanese adults. Thus, an effective screening program that identifies people with hypertriglyceridemia is warranted.