Abstract
The article presents modern approaches to the modulation of cellular factors of innate immunity, oxidative stress factors when using a hypertonic seawater solution withAscophillum nodosumbrown algae extract (NaCl 15 g/l) in patients with acute rhinosinusitis.Characteristics of the children and research methods. The authors examined 102 children aged from 5 to 8 years, with a history of more than 5 episodes of acute rhinosinusitis per year. We evaluated the quantitative and qualitative composition of neutrophilic granulocytes in washes from the mucous membrane of the nasal cavity, the production of reactive oxygen species (ROS) by neutrophilic granulocytes, the content of lipid peroxidation products, enzymes of the antioxidant system – superoxide dismutase and catalase in nasal washes.Results.The authors found that the nasal spray of a hypertonic seawater solution withAscophillum nodosumbrown algae extract helps to normalize clinical picture, reduce number of relapses, restore functional and metabolic status of neutrophils of the nasal mucosa surface, restore balance of lipid peroxidation factors, antioxidant sustem enzymes – superoxide dismutase and catalase.
Highlights
Представлены данные о современных подходах к вопросам модуляции клеточных факторов врожденного иммунитета, факторов окислительного стресса при использовании гипертонического раствора морской воды с экстрактом бурых водорослей Ascophillum nodosum у пациентов с острым риносинуситом
We evaluated the quantitative and qualitative composition of neutrophilic granulocytes in washes from the mucous membrane of the nasal cavity, the production of reactive oxygen species (ROS) by neutrophilic granulocytes, the content of lipid peroxidation products, enzymes of the antioxidant system – superoxide dismutase and catalase in nasal washes
The authors found that the nasal spray of a hypertonic seawater solution with Ascophillum nodosum brown algae extract helps to normalize clinical picture, reduce number of relapses, restore functional and metabolic status of neutrophils of the nasal mucosa surface, restore balance of lipid peroxidation factors, antioxidant sustem enzymes – superoxide dismutase and catalase
Summary
Представлены данные о современных подходах к вопросам модуляции клеточных факторов врожденного иммунитета, факторов окислительного стресса при использовании гипертонического раствора морской воды с экстрактом бурых водорослей Ascophillum nodosum (содержание NaCl 15 г/л) у пациентов с острым риносинуситом. Важной составляющей терапии риносинусита является очищение слизистой оболочки полости носа и околоносовых пазух от патогенов, наличие которых усиливает окислительный стресс, угнетает факторы местной антимикробной защиты. Средство для орошения полости носа Аквалор Протект® можно рассматривать как инновационное, поскольку в его составе, помимо традиционных компонентов – морской и очищенной воды, содержится 0,1% экстракт бурых водорослей (Ascophillum nodosum).
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