Abstract
In two series of cases we studied the effect on the heart of the intravenous injection of hypertonic glucose solution. In Group I it was observed that in patients with effort angina and coronary arteriosclerosis the injection of hypertonic glucose solution produced marked electrocardiographic changes and frequently caused pain. In Group II it was observed that patients with effort angina and pathologic alterations of the electrocardiogram after exercise developed the same, and even more marked, alterations of the electrocardiogram when hypertonic glucose solution was given shortly before the performance of the exercise test. The various theories concerning the effect of hypertonic glucose solution on the blood and coronary arteries were discussed, and the possible causes for the production of cardiac pain after the injection of hypertonic glucose solution were reviewed.
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