Hyperthyroidism selectively increases oxidative metabolism of slow-oxidative motor units

Abstract

The effects of thyroid hormone on the NADH-tetrazolium reductase activity (oxidative metabolism marker) of soleus (slow-oxidative) and tensor fascia lata (fast-glycolytic) motoneurons were determined and compared with changes in a variety of enzyme activities in the corresponding muscle fibers. Histochemical assays have demonstrated a selective and qualitative conversion in muscle fiber ATPase and quantitative increases of NADH-tetrazolium reductase (oxidative) and mitochondrial α-glycerophosphate dehydrogenase (glycolytic) activities in the soleus muscle. Paralleling the selective action upon the soleus slow muscle fibers was a selective central nervous system effect of thyroid hormone on oxidative enzymes of soleus slow-oxidative motoneurons. This indicates that either thyroid hormones act directly and specifically on slow motoneurons or that conversion of the muscle fibers by thyroid hormones produces secondary changes in the motoneuron. These data strengthen the hypothesis that oxidative enzyme activities in motoneurons are tightly matched with oxidative enzyme activities in muscle fibers.