Abstract
The presenting symptoms of hyperthyroidism are mainly attributable to the effect of the excessive production of thyroid hormones. The involvement of the entire body in the hyperthyroid syndrome is due to the widespread distribution of T3 receptors in tissues, the cardiovascular system and the muscles being the main target for thyroid hormone. The biochemical diagnosis of hyperthyroidism is characterized by elevated serum concentrations of T4 and T3 in the presence of low or undetectable serum TSH concentrations. The measurement of serum TSH-receptor autoantibodies (TRAb) will help confirm the diagnosis of Graves’ disease. The first goal of the treatment is the prompt control of the signs and symptoms of thyrotoxicosis, and is usually achieved by thionamides. If hyperthyroidism persists after 18–24months, a definitive treatment by surgical thyroidectomy or radioactive iodine ablation is suggested.
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