Abstract
ABSTRACT The testosterone plasma concentration, metabolic clearance rate of testosterone, sexual binding protein (S.B.P.) concentration and the conversion of iv injected labeled testosterone to urinary androstanediols (androstanediol and 5βandrostanediol) have been evaluated in a hyperthyroid subject with gynecomastia. Results have been compared with those obtained in normal men, in a man treated with estrogen and in a hypogonadal subject. The thyrotoxic state is a very particular condition where, in spite of an elevated S.B.P. concentration, the conversion of testosterone to urinary androstanediol is not reduced. The cutaneous 5α-reductase activity for testosterone, which may be considered as the ratio of potential conversion of percutaneously administered testosterone to the conversion of intravenously injected testosterone to androstanediol, is not very different in the hyperthyroid subject compared to that observed in normal males. Gynecomastia is possibly explained by an elevated concentration of pla...
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