Abstract
The combined effect of hyperthermis and doxorubicin on the neurogenic rat cell line BT 4C was found to be synergistic in vitro. The present investigation was initiated to study if this synergistic effect also could be obtained in vivo. An enhanced effect occurred when doxorubicin and 4′-epi-doxorubicin 7 mg/kg body weight were given 30 minutes prior to local water bath hypertbermia (one hour at 44.0 °C). The local side effects of the combined treatment did not increase above that of bypertbermia alone. Therefore, local byperthermia may become a useful modality for enhancement of the effect of anthracyclines on tumors with marginal drug sensitivity or bulky tumors with poor drug penetration.
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More From: International Journal of Radiation Oncology, Biology, Physics
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