Abstract
Cell killing and the induction and repair of DNA strand breaks have been examined after hyperthermia and electron irradiation treatments of HeLa S3 cells. Heat alone did not produce any detectable DNA strand breaks. Preirradiation heat treatment did not alter the initial levels of radiation-induced DNA strand breaks. However, the subsequent rate and extent of DNA strand break repair were significantly reduced by preirradiation heat treatments of 44/sup 0/C for 30 or 60 min. When a time gap of up to 1 h was introduced between heating and irradiation there was no significant reduction of the thermal enhancement effect for cell killing or recovery from the reduced ability to repair DNA strand breaks.
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