Abstract
Extravasation in the heart, liver, lung, kidney, spleen, gastrocnemius, and duodenum was quantified in normothermic and hyperthermic (core temperature ( T c)=41.5, 42, or 42.6°C) rats. Following attainment of the target T c, Evans blue (Eb) was administered via jugular cannula; the animals were anesthetized, exsanguinated, tissues removed and washed in saline, and Eb extracted with formamide. There was significantly ( p<0.05) more Eb (μg/g of dry wt of tissue, mean±SD) in the tissues of severely hyperthermic ( T c=42.6°C) rats vs that of control rats: liver — 198±39 vs 125±28, kidney — 376±68 vs 176±60, and small intestine — 170±49 vs 106±20. This model may be useful in evaluating the efficacy of treatment modalities designed to sustain vascular integrity in the face of environmental insult.
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