Abstract
PURPOSE: We recently reported that increasing airway temperature induced a transient airway constriction in anesthetized guinea pigs with activation of transient receptor potential vanilloid type 1 (TRPV1) channels being primarily responsible (J. Appl. Physiol. 106: 1917-24, 2009). TRPV1 channels expressed on bronchopulmonary C-fiber vagal afferents are polymodal sensors and can be activated by increasing temperature in the airways. Stimulation of these sensory nerves is known to elicit bronchoconstriction via the cholinergic pathway. This pilot study was designed to confirm these observations made in the animal study and to test our hypothesis that airway hyperthermia-induced bronchoconstriction in asthmatics is mediated through the cholinergic pathway.
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