Abstract
Iron oxide nanoparticles are intended to be used in bio-applications for drug delivery associated with hyperthermia. However, their interactions with complex media often induces aggregation, and thus a detrimental decrease of their heating efficiency. We have investigated the role of iron oxide nanoparticles dispersion into dense aggregates composed with magnetic/non-magnetic nanoparticles and showed that, when iron oxide nanoparticles were well-distributed into the aggregates, the specific absorption rate reached 79% of the value measured for the well-dispersed case. This study should have a strong impact on the applications of magnetic nanoparticles into nanostructured materials for therapy or catalysis applications.
Highlights
Magnetic hyperthermia is a powerful technique envisaged to heat up materials or tissues
Recovering high Specific loss loss power power (SLP) values during application is really important because this normalized value is the one that is used to compare the efficiency of iron oxide nanoparticles directly depending on their synthesis procedure
To avoid detrimental dipolar interaction in nanostructured systems, we mixed iron coated with respect to the existing procedures described in materials and methods
Summary
Magnetic hyperthermia is a powerful technique envisaged to heat up materials or tissues. Used as probes for cancer therapy, iron oxide nanoparticles are largely studied coupled to hyperthermia to activate cell death [1] or molecular release. Iron oxide nanoparticles are non-toxic [2], and eliminated by the cells in vivo [3]. The heating properties of iron oxide nanoparticles are often deteriorated by their aggregation [1,4]. This involves a drastic decrease of the specific loss power (SLP, or SAR in some publication, for specific absorption rate), which corresponds to the heat energy loss by the particles toward their environment [5]. Optimized nanoparticles excited with the right frequencies demonstrate large SLP values (see, for instance, the work of Fortin et al [6])
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