Abstract
To the Editor.— In addition to conventional therapeusis employed for the treatment of cancer (eg, chemotherapy, radiation therapy, and surgery), the use of hyperthermia and hypothermia as a means of selectively destroying malignant cells received increased attention in the 1960s. 1 Renewed interest in hyperthermia isexemplified by the recent article of LeVeen et al (235:2198, 1976) and an editorial inThe Journal(235:2223, 1976). Earlier studies by Strauss et al 2 suggested induction of an immunologic response in patients with rectal carcinoma after fulguration of their tumor as one possible explanation for observations of regression of tumor in patients so treated. As one of several approaches in evaluating the effect of hyperthermia on immunologic responsiveness, we have compared the reactivity of leukocytes from patients with genitourinary tumors to unheated and heated allogeneic tissue extracts. Employing antigen-induced leukocyte adherence inhibition 3 with 3M potassium chloride extracts of allogeneic carcinomatous tissue,
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