Abstract
Hypertensive disorders of pregnancy: Case definitions & guidelines for data collection, analysis, and presentation of immunization safety data
Highlights
One leading hypothesis is that abnormalities in the development of the uteroplacental unit lead to increased hypoxemia and oxidative stress, which in turn lead to endothelial dysfunction and abnormalities in vascular tone and coagulation [3,4]
Hypertensive disease in pregnancy encompasses a spectrum of conditions, including gestational hypertension, preeclampsia, eclampsia, chronic hypertension with superimposed preeclampsia and HELLP (Hemolysis, Elevated Liver Enzymes, Low Platelets) syndrome
The following guidelines represent a desirable standard for analysis of data on the hypertensive disorders of pregnancy to allow for comparability of data, and are recommended as an addition to data analyzed for the specific study question and setting
Summary
While complications of pregnancy such as intrauterine growth restriction, placental abruption and stillbirth are utilized as diagnostic criteria for preeclampsia with severe features by some societies [15,16], the Brighton Collaboration has chosen not to include these in our definition since these conditions frequently exist independently of the hypertensive disorders of pregnancy and may represent a separate set of pathologies. We recommend that these complications should certainly be reported as pregnancy outcomes in the context of vaccine and other drug trials. Ensuring accurate diagnosis is of great importance, as treatment can vary widely based on the etiology of the patient’s symptoms
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