Abstract
BackgroundWe investigated the relationship between the preoperative hypertension and prognosis of esophageal squamous cell cancer (ESCC) patients who had underwent esophagectomy.ResultsWe detected 52% patients with hypertension, including 317 patients with newly diagnosed hypertension and 194 patients with history of hypertension. Compared with patients of normal blood pressure, all patients with hypertension and newly diagnosed hypertension were observed to have worse overall and ESCC-specific survival outcome (p < 0.05). After adjusted in multivariate Cox regression analysis, hypertension (HR: 1.343, 95% CI: 1.064, 1.695; HR: 1.315, 95% CI: 1.039, 1.664) and newly diagnosed hypertension (HR: 1.414, 95% CI: 1.095, 1.826; HR: 1.420, 95% CI: 1.098, 1.836) were inversely associated with overall and ESCC-specific survival outcome, respectively. While no association was found between history of hypertension and overall or ESCC-specific survival outcome (HR: 1.229, 95% CI: 0.892, 1.694; HR: 1.132, 95% CI: 0.812, 1.578).ConclusionsHypertension was an independent risk factor and resulted in inferior prognosis for ESCC patients who had underwent esophagectomy.MethodsA total of 982 ESCC patients who had underwent esophagectomy from August 2010 to December 2015 were enrolled in our study with a follow up of 6 years. The Kaplan-Meier method and log-rank test were respectively used to calculate and compare survival rate, and Cox proportional hazards regression model was applied to identify independent prognostic factors.
Highlights
Esophageal cancer (EC) with higher incidence and mortality has been still an aggressive malignant tumors worldwide [1]
We investigated the relationship between the preoperative hypertension and prognosis of esophageal squamous cell cancer (ESCC) patients who had underwent esophagectomy
After adjusted in multivariate Cox regression analysis, hypertension (HR: 1.343, 95% confidence intervals (CIs): 1.064, 1.695; hazard ratios (HRs): 1.315, 95% CI: 1.039, 1.664) and newly diagnosed hypertension (HR: 1.414, 95% CI: 1.095, 1.826; HR: 1.420, 95% CI: 1.098, 1.836) were inversely associated with overall and ESCC-specific survival outcome, respectively
Summary
Esophageal cancer (EC) with higher incidence and mortality has been still an aggressive malignant tumors worldwide [1]. EC is one of the highest prevalence tumors and the fourth leading cause of cancer-related death in China, and its age-standardized 5-year survival rate was only 20.9% [2]. The esophageal squamous cell carcinoma (ESCC) is the predominant histological type and accounts for over 90% of EC in China [1, 3]. Surgical resection has remained the mainstream treatment for ESCC. The long-term outcomes after esophagectomy are still not ideal, with the average 5-year survival rates at 20–30% [4, 5]. It is necessary to detect the www.impactjournals.com/oncotarget risk factors associated to prognosis of ESCC patients after surgical resection and further adopting adjunctive therapy to make it control. We investigated the relationship between the preoperative hypertension and prognosis of esophageal squamous cell cancer (ESCC) patients who had underwent esophagectomy
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