7-days of FREE Audio papers, translation & more with Prime
7-days of FREE Prime access
7-days of FREE Audio papers, translation & more with Prime
7-days of FREE Prime access
https://doi.org/10.1111/j.1600-0404.1978.tb02897.x
Copy DOIJournal: Acta Neurologica Scandinavica | Publication Date: Jan 29, 2009 |
Citations: 9 |
Ethanol has been shown to aggravate the blood-brain barrier (BBB) dysfunction in cerebral trauma and in cerebral gas embolism, possibly by changing the endothelial cell membrane. No difference in protein extravasation was found between intoxicated and control rats under nitrous oxide anesthesia after the injection of bicuculline, a drug that hemodynamically gives rise to high blood pressure in combination with cerebral vasodilatation. In contrast there was a statistically significant increase in protein leakage in conscious intoxicated rats. The fact that ethanol increased the vulnerability only in conscious rats might indicate that nitrous oxide and ethanol have a common effect on the endothelial cell membranes or that nitrous oxide neutralizes an action of ethanol. Protein leakage induced by acute hypertension is more severe in rats anesthetized with nitrous oxide than in conscious rats, a difference that might to some extent be related to an effect of nitrous oxide on the endothelial cells. Further studies are needed to evaluate the influence of ethanol and nitrous oxide on the endothelial cell membrane.
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.