Abstract
Psoriasis is a chronic inflammatory skin disease that is characterized by T-cell mediated immune response, and has been known to increase the risk of developing hypertension. However, the risk of psoriasis in patients with hypertension is not clear. Therefore, we investigated the risk of psoriasis in patients with hypertension. A total of 256,356 adults (42,726 in the hypertension group and 213,630 in the control group) were followed from 2003 to 2013 in a nationwide population-based cohort study. During the follow-up, 9,254 participants (3.6%) were found to have psoriasis (2,152 [5.0%] in the hypertension group and 7,102 [3.3%] in the control group). The hypertension group had a higher risk of psoriasis incidence (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.47–1.61, P < 0.001), and the association remained significant after adjusting for comorbidities of diabetes and dyslipidemia, antihypertensive medication and nonsteroidal anti-inflammatory drug use, and sociodemographic factors (HR 1.18, 95% CI 1.08–1.28, P < 0.001). In conclusion, hypertension was significantly associated with an increased risk of psoriasis incidence. Further studies are needed to confirm whether hypertension is associated with the incidence of psoriasis.
Highlights
Psoriasis is a chronic inflammatory skin disease related T-cell mediated immune mechanisms [1]
Sex, or residential area were detected between the subjects with and without hypertension, but there were significant differences in the prevalence of diabetes and dyslipidemia, antihypertensive medication and nonsteroidal anti-inflammatory drugs (NSAIDs) use, and household income between the two groups
The use of calcium channel blockers (CCBs) or thiazides was associated with a higher risk of psoriasis incidence after adjusting for the aforementioned covariates (HR 1.14, 95% CI 1.05–1.23, P = 0.002, and HR 1.10, 95% CI 1.02–1.18, P = 0.010, respectively)
Summary
Psoriasis is a chronic inflammatory skin disease related T-cell mediated immune mechanisms [1]. Several studies have reported positive associations between psoriasis and hypertension [10,11]. Most studies show that patients with psoriasis have a higher risk of hypertension [10,12]. Hypertension and risk of psoriasis incidence prospective studies investigating the association between hypertension and the risk of psoriasis development are rare. Wu et al conducted a prospective study of the association between hypertension and the risk of psoriasis in US women [13], but no studies to date have evaluated the risk of psoriasis in men as well as women with hypertension. We investigated the association between hypertension and the prospective risk of psoriasis development using the National Health Insurance Service National Sample Cohort (NHIS-NSC) 2002–2013 that was produced by the Korean National Health Insurance Service (KNHIS)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
