Abstract
The topic of hypertension is one that has received an enormous amount of attention during the past 50 years. The pathology has been extensively described and investigated, and the role of the kidney, including the thousands of studies on the renin-angiotensin system, has been of continuing intense interest. The contributions of neurohumoral influences on hypertension have also been vigorously studied, and the clinical and epidemiologic features have been subject to intense scrutiny—to mention only some of the areas of concern. Great expectations for an early cure of hypertension when the Goldblatt kidney preparation (1934) and renin (1939) were first described were not realized with the passage of time. The mosaic theory of Page 1 emphasized the complexity of the problem and the existence and the interrelations of multiple forces leading to a common event—raised arterial BP. Forms of treatment existing in the 1930s and 1940s were not satisfactory, including the
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