Abstract
Geometrical 3D models of human red blood cells in dry smear were obtained experimentally using hyperspectral holography technique. Corresponding diffraction patterns in the far field diffraction zone were calculated. Visibility values of the diffraction patterns were obtained in cases of low and high red cell distributions width (RDW). Our study reveals that although the visibility is influenced by the cells shapes, this parameter can still be used to assess red cell distribution width in clinical practice.
Highlights
Modern medical diagnostics is based on blood tests that allow one to insure diagnosis with high accuracy
The erythrocytes shape is strongly influenced by the sample preparation and experimental protocols
As one can see from the Function 4 in Fig. 5 the obtained shape changes the visibility value critically
Summary
Modern medical diagnostics is based on blood tests that allow one to insure diagnosis with high accuracy. Red cell distribution width (RDW) is known as a crucial parameter in case of blood anemia. RDW is a measure of how much the erythrocytes differ from each other in size. RDW is close to zero, when all cells have similar size, and increases when the sizes are different. RDW has been evaluated for decades, and its application field grows rapidly. Recent investigation performed with more than 8000 people shows that RDW serves as a reliable mortality predictor independent of the disease type, see Ref. Accurate diagnostic instruments for measuring this parameter are in high demand
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